Fahime Hashemi; Shayan Vafaei; Mehdi Sadeghi; Atena Samarehfekri; Mitra Samarehfekri; Hossein Mirzaei; Niloofar Rashidipour; Mozhgan Taebi
Volume 25, Issue 5 , 2023
Abstract
Background: Coronavirus disease (COVID-19) is a viral disease that mostly affects the respiratory system and leads to respiratory failure. Alongside, pulmonary rehabilitation is one of the most important components in the management of respiratory system diseases and can rehabilitate persons after lung-damaged ...
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Background: Coronavirus disease (COVID-19) is a viral disease that mostly affects the respiratory system and leads to respiratory failure. Alongside, pulmonary rehabilitation is one of the most important components in the management of respiratory system diseases and can rehabilitate persons after lung-damaged disease.
Objectives: The present study aimed to determine the efficiency of Home-Based Pulmonary Rehabilitation in pulmonary function in patients with COVID-19
Methods: This simple randomized interventional study was conducted on 70 COVID-19 patients in Kerman, Iran. They were assigned to two equal groups of control and intervention. In the control group, patients received only routine post-discharge care, and in the intervention group, patients received home-based pulmonary rehabilitation procedures containing some movements to improve pulmonary function for four weeks after discharge.
Results: Forced expiratory volume in 1 second (P<0.001), vital capacity (P<0.001) and these two parameters ratio (P<0.02), peak expiratory flow (P<0.001), in four weeks after discharge from the hospital in the intervention group was significantly higher than in the control group. Moreover, 6-min walk distance (P<0.001) was significantly increased, and the severity of dyspnea (P<0.001) was significantly reduced in the intervention group. As well, the number of patients with severe dyspnea decreased significantly (P<0.001).
Conclusion: It seems that our home-based program can result in a marked improvement in vital capacity and other pulmonary function tests, as well as a reduction in dyspnea after discharge. In conclusion, this rehabilitation procedure is effective in pulmonary recovery in COVID-19 patients and can be used as a treatment procedure for recovery in these patients.
Amir Hossein Sarrami; Mehdi Karami; Mehdi Sadeghi; Behzad Haddad
Volume 19, Issue 5 , May 2017, , Pages 1-3
Abstract
Background: Cystic echinococcosis of soft tissue is rare even in endemic areas. Intermuscular and intramuscular cystic echinococcoses have been occasionally reported in the literature.Case Presentation: A 40-year-old male was referred to the surgery clinic of Alzahra Hospital, Isfahan, Iran, with a ...
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Background: Cystic echinococcosis of soft tissue is rare even in endemic areas. Intermuscular and intramuscular cystic echinococcoses have been occasionally reported in the literature.Case Presentation: A 40-year-old male was referred to the surgery clinic of Alzahra Hospital, Isfahan, Iran, with a swelling over the right side of his chest in September 2015. In physical examination, a nontender soft bulging in depth of the right pectoralis major muscle with no skin manifestation was noticeable. The axial and coronal contrast-enhanced CT scan showed a multicystic mass lesion between the right pectoralis major and minor muscles with extension beneath the pectoralis minor muscle. The patient underwent a surgery for resection of the mass. After dissection of the pectoralis major fascia, a large cystic mass was visualized just beneath the muscle with some adhesion to the chest wall. Histopatholgic study of the surgical specimen also revealed cystic echinococcosis.Conclusions: This case reveals that cystic echinococcosis should be considered in differential diagnoses of any chest wall swelling.
Samiie Pouragahi; Marjan Nassiri-Asl; Mohammad Ali Sahraian; Mehdi Sadeghi; Abdolali Banki; Mitra Ataei; Mohammad Hossein Sanati
Volume 19, Issue 3 , March 2017, , Pages 1-10
Abstract
Background: Myelin basic protein (MBP), a crucial neuro-autoantigen involved in the maintenance of the myelin sheath, is one of the biomarkers of therapeutic response in multiple sclerosis (MS).Objectives: The study examines prognostic biomarker and molecular mimicry hypothesis MS etiology by MBP.Methods: ...
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Background: Myelin basic protein (MBP), a crucial neuro-autoantigen involved in the maintenance of the myelin sheath, is one of the biomarkers of therapeutic response in multiple sclerosis (MS).Objectives: The study examines prognostic biomarker and molecular mimicry hypothesis MS etiology by MBP.Methods: This study is convergence of three arms including in silico and in vitro (bioinformatics) with the in vivo (experimental). A novel methodology combining molecular techniques was used to confirm the antigenic properties of MBP and study its efficiency in increasing the susceptibility to MS. One hundred eighty MS patients and healthy subjects were recruited for the study from Jan 2013 to Feb 2016 in Iran. Age and sex-matched healthy volunteers and patients were analyzed using various quantitative and qualitative molecular laboratory techniques. Peripheral blood mononuclear cells (PBMCs) and plasma was used for the retrieval of MBP and IgG assay, respectively.Results: The optimum concentration of the MBP epitope for the immune system to react and facilitate prognostication was found to be 50 and 150 µg/mL in MS patients and healthy individuals, respectively (P < 0.0001****). Combined results from ELISA and realtime PCR showed that the total IgG and the ratio of gene expression for candidate human MBP epitope was higher in MS patients in all the three groups compared to that in healthy controls P < 0.0001****).Conclusions: Molecular assays in the early stages of the disease could help in elucidating the effectiveness of the MBP as a prognostic factor in MS.
